Product Name :
NF110
Description:
NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons.
CAS:
111150-22-2
Molecular Weight:
1096.91
Formula:
C41H28N6Na4O17S4
Chemical Name:
tetrasodium 4-3-[(3,5-bis[(4-sulfonatophenyl)carbamoyl]phenylcarbamoyl)amino]-5-[(4-sulfonatophenyl)carbamoyl]benzamidobenzene-1-sulfonate
Smiles :
[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1C=CC(=CC=1)NC(=O)C1=CC(=CC(=C1)C(=O)NC1C=CC(=CC=1)S([O-])(=O)=O)NC(=O)NC1C=C(C=C(C=1)C(=O)NC1C=CC(=CC=1)S([O-])(=O)=O)C(=O)NC1C=CC(=CC=1)S([O-])(=O)=O
InChiKey:
AQJHZNCSXLBXMY-UHFFFAOYSA-J
InChi :
InChI=1S/C41H32N6O17S4.4Na/c48-37(42-27-1-9-33(10-2-27)65(53,54)55)23-17-24(38(49)43-28-3-11-34(12-4-28)66(56,57)58)20-31(19-23)46-41(52)47-32-21-25(39(50)44-29-5-13-35(14-6-29)67(59,60)61)18-26(22-32)40(51)45-30-7-15-36(16-8-30)68(62,63)64;;;;/h1-22H,(H,42,48)(H,43,49)(H,44,50)(H,45,51)(H2,46,47,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64);;;;/q;4*+1/p-4
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Trastuzumab deruxtecan Antibody-drug Conjugate/ADC Related
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons.Diclosulam supplier |Product information|CAS Number: 111150-22-2|Molecular Weight: 1096.PMID:34928343 91|Formula: C41H28N6Na4O17S4|Chemical Name: tetrasodium 4-3-[(3,5-bis[(4-sulfonatophenyl)carbamoyl]phenylcarbamoyl)amino]-5-[(4-sulfonatophenyl)carbamoyl]benzamidobenzene-1-sulfonate|Smiles: [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1C=CC(=CC=1)NC(=O)C1=CC(=CC(=C1)C(=O)NC1C=CC(=CC=1)S([O-])(=O)=O)NC(=O)NC1C=C(C=C(C=1)C(=O)NC1C=CC(=CC=1)S([O-])(=O)=O)C(=O)NC1C=CC(=CC=1)S([O-])(=O)=O|InChiKey: AQJHZNCSXLBXMY-UHFFFAOYSA-J|InChi: InChI=1S/C41H32N6O17S4.4Na/c48-37(42-27-1-9-33(10-2-27)65(53,54)55)23-17-24(38(49)43-28-3-11-34(12-4-28)66(56,57)58)20-31(19-23)46-41(52)47-32-21-25(39(50)44-29-5-13-35(14-6-29)67(59,60)61)18-26(22-32)40(51)45-30-7-15-36(16-8-30)68(62,63)64;;;;/h1-22H,(H,42,48)(H,43,49)(H,44,50)(H,45,51)(H2,46,47,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64);;;;/q;4*+1/p-4|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NF110 shows an activity in the human tumour cell line panel, with IC30 of 362.3 μM. NF110 inhibits HMGA2-DNA interactions with an IC50 of 0.87 μM.|In Vivo:|NF110 shows potency at Endogenous P2X Receptors in Rat DRG Neurons, with a peak amplitude of 675 pA.|Products are for research use only. Not for human use.|
