Mouse IL-18BP Protein 3979

Additional Information:
accession Q9Z0M9|express systemHEK293|product tagC-hFc|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundCytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.|molecular weightThe protein has a predicted MW of 44.7 kDa. Due to glycosylation, the protein migrates to 60-75 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse IL-18BP Protein 3979proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceCytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.Protein namesInterleukin-18-binding protein (IL-18BP) (Interferon gamma-inducing factor-binding protein)Gene namesIl18bp,Il18bp IgifbpMass10090DaFunctionBinds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity).Subellular locationSecreted .Target Relevance information above includes information from UniProt accession: Q9Z0M9The UniProt Consortium|