Mouse SELL/CD62L Protein 3667

Additional Information:
inaccessionP18337|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundL-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterized as a tethering/rolling receptor. There is now mounting evidence in the literature to suggest that L-selectin plays a role in regulating monocyte protrusion during transendothelial migration (TEM).|molecular weightThe protein has a predicted MW of 34.2 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse SELL/CD62L Protein 3667proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceL-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterized as a tethering/rolling receptor. There is now mounting evidence in the literature to suggest that L-selectin plays a role in regulating monocyte protrusion during transendothelial migration (TEM).Protein namesL-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)Gene namesSell,Sell Lnhr Ly-22 Ly22Protein familySelectin/LECAM familyMass10090DaFunctionCalcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes (PubMed:1693096). Promotes initial tethering and rolling of leukocytes in endothelia (By similarity).Catalytic activityBINDING 118; /ligand=”Ca(2+)”; /ligand_id=”ChEBI:CHEBI:29108″; /evidence=”ECO:0000250|UniProtKB:P14151″; BINDING 120; /ligand=”Ca(2+)”; /ligand_id=”ChEBI:CHEBI:29108″; /evidence=”ECO:0000250|UniProtKB:P14151″; BINDING 126; /ligand=”Ca(2+)”; /ligand_id=”ChEBI:CHEBI:29108″; /evidence=”ECO:0000250|UniProtKB:P14151″; BINDING 143; /ligand=”Ca(2+)”; /ligand_id=”ChEBI:CHEBI:29108″; /evidence=”ECO:0000250|UniProtKB:P14151″; BINDING 144; /ligand=”Ca(2+)”; /ligand_id=”ChEBI:CHEBI:29108″; /evidence=”ECO:0000250|UniProtKB:P14151″Subellular locationCell membrane ; Single-pass type I membrane protein .TissuesPredominantly expressed in lymphoid tissue.StructureInteraction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on ‘Tyr-51’ of SELPLG is important for L-selectin binding.Post-translational modificationN-glycosylated.Target Relevance information above includes information from UniProt accession: P18337The UniProt Consortium|