DUSP18 Enzyme

Description:
|Introduction Dual specificity Phosphatase 18 (DUSP18) belongs to the dual-specificity Phosphatase (DSP) family, which catalyzes dephosphorylation of phosphotyrosine and phosphothreonine residues. DUSP18 has a preferential enzymatic activity for phosphorylated tyrosine residues over threonine residues, in addition DUSP18 dephosphorylates p-nitrophenyl phosphate (pNPP) in vitro. Furthermore, DUSP18 is inhibited by iodoarectic acid and is activated by manganese ions. DUSP18 is extensively expressed with the highest levels in the liver, brain, ovary and testis. |Reco|E. coli-derived. A single, non-glycosylated polypeptide chain containing 212 amino acids (1-188) and having a molecular mass of 23.6 kDa. DUSP18 is fused to a 24 amino acid His-tag at N-terminus. Purity: > 95% as determined by SDS-|The DUSP18 solution (0.5 mg/ml) contains 20 mM Tris-HCl buffer (pH 8.0), 1 mM DTT, 40% glycerol, 0.1 mM PMSF and 1 mM EDTA. Shipping: The product is shipped with ice |Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.