Latelet-derived development nNOS Gene ID factor receptor, Platelet-derived growth element receptor, LDLR-related protein 1 Platelet-derived growth aspect receptor, Platelet-derived growth element receptor, Sphingosine-1-phosphate receptor 1 Platelet-derived development aspect receptor, Platelet-derived development factor receptor, Opioid growth aspect receptor Plexin B2 Protein tyrosine phosphatase, receptor type, B Syndecan 1 Syndecan 3 Retinoic acid receptor responder 2 Reelin Semaphorin 3C Semaphorin 3F Chemokine (C-C motif) receptor-like 2 Integrin, 3 Plexin D1 Neuropilin 1 Neuropilin 2 Semaphorin 4C Semaphorin 6D Secreted frizzledrelated protein 1 Slit homolog two Transforming development factor, 1 Plexin B2 Kinase insert domain receptor Frizzled class receptor 6 Syndecan 1 Activin A receptor sort II ike 1 CD109 molecule Syndecan two Transforming growth issue, receptor two (Continued)Table 1. ContinuedGene Pair TGFB1_TGFBR3 TGFB2_ ACVR1 TGFB2_ENG TGFB2_TGFBR2 TGFB2_TGFBR3 TGFB3_TGFBR2 TGFB3_TGFBR3 TNFSF12_ TNFRSF12A TNFSF12_ TNFRSF25 TNFSF13_FAS TNFSF13_SDC2 TNFSF13_ TNFRSF1A VEGFA_SIRPA VEGFA_TYRO3 VEGFC_FLT1 VEGFC_FLT4 VEGFC_ITGB1 VEGFC_KDR VEGFC_LYVE1 VEGFC_NRP2 WNT4_FZD6 Wingless-type MMTV integration internet site 4 Vascular endothelial growth element C Vascular endothelial development element A TNF superfamily, member 13 TNF superfamily, member 12 Transforming growth factor, 3 Transforming growth factor, two Ligand Receptor Transforming growth factor, receptor three Activin A receptor, type I Endoglin Transforming growth aspect, receptor 2 Transforming growth factor, receptor three Transforming growth element, receptor two Transforming growth factor, receptor 3 TNF receptor superfamily, member 12A TNF receptor superfamily, member 25 Fas cell surface death receptor Syndecan 2 TNF receptor superfamily, member 1A Signal-regulatory protein TYRO3 protein tyrosine kinase Fms-related tyrosine kinase 1 Fms-related tyrosine kinase 4 Integrin, 1 Kinase insert domain receptor Lymphatic vessel endothelial hyaluronan rec 1 Neuropilin 2 Frizzled class receptorPTN_SDC1 PTN_SDC3 RARRES2_ CCRL2 RELN_ITGA3 SEMA3C_ PLXND1 SEMA3F_NRP1 SEMA3F_NRP2 SEMA4C_ PLXNB2 SEMA6D_KDR SFRP1_FZD6 SLIT2_SDC1 TGFB1_ ACVRL1 TGFB1_CD109 TGFB1_SDC2 TGFB1_TGFBRThis table is restricted to signaling proteins, cytokines, growth elements, and chemokines. For other cell-surface ligand-receptor pairs, we refer to Information S1. BMP indicates bone morphogenetic protein; CD, cluster of differentiation; EGF, epidermal development aspect; LDLR, low-density lipoprotein receptor; MMTV, mouse mammary tumor virus; PDGF, platelet-derived development issue; TEK, endothelial tyrosine kinase; TK, tyrosine kinase; TNF, tumor necrosis aspect; TYRO, tyrosine-protein kinase receptor; and Wnt, wingless-type integration web-site family members, member 1.a further 10 are expressed by both cardiomyocytes and fibroblasts (Table S3); just 4 are expressed PLK4 drug specifically by cardiomyocytes. If one considers not just the ligands but the comprehensive 79 ligand-receptor pairs expressed by cardiomyocytes, 31 are expressed by all 3 cell sorts and a different 36 are expressed by each cardiomyocytes and fibroblasts; just 9 are expressed especially by cardiomyocytes. What is also fascinating is the fact that most ligands expressed by all three cellJ Am Heart Assoc. 2021;ten:e019169. DOI: 10.1161/JAHA.120.Segers et alAutocrine Signaling in the HeartTable two. Ligands Expressed by Cardiomyocytes, Endothelial Cells, and FibroblastsGene ADM ANGPT2 ANXA1 CTGF CXCL12 CYR61 DKK1 GAS6 HGF IGF2 JAG1 MDK NPPB PDAP1 PDG.
