Ng, Naqvi, et al. eLife 2021;ten:e58615. DOI: https://doi.org/10.7554/eLife.28 ofResearch short article.Genetics and GenomicsSupplementary file 12. Phenotype-level correlations amongst luteinizing hormone (LH) and testosterone in females and males. Magnitude of correlation and sample sizes are each higher making use of the XM0lv luteinizing hormone code, but outcomes are consistent across codes..Transparent reporting formData availability Full raw summary statistics and relevant processed data tables are out there on Figshare (https://doi. org/10.6084/m9.figshare.c.5304500.v1), or the lab website (http://web.stanford.edu/group/pritchardlab/dataArchive.html, direct hyperlink to google drive https://drive.google.com/drive/u/3/folders/ 10hCG_Wz8f25E6_sxw6sB8vDtS2OWUW9E). The following dataset was generated:Author(s) Naqvi S Year Dataset title 2021 Supplementary Information for SinnottArmstrong and Naqvi Dataset URL Database and Identifierhttps://doi.org/10.6084/ figshare, ten.6084/m9. m9.figshare.c.5304500.v1 figshare.c.5304500.vThe following previously published datasets were employed:Author(s) MEK Activator Storage & Stability Mesirov J, Tamayo P, Castanza A, Eby D, Medetgul-Ernar K, Niklason J, Reich M, Subramanian A, Thorvaldsdottir H, Wenzel A, Xu X Year 2019 Dataset title MSigDB Dataset URL http://software.broadinstitute.org/gsea/msigdb/ Database and Identifier GSEA, msigdb
moleculesArticleExploratory Study Making use of Urinary Volatile Organic Compounds for the Detection of Hepatocellular CarcinomaAyman S. Bannaga 1,2 , Heena Tyagi three , Emma Daulton 3 , James A. Covington three and Ramesh P. Arasaradnam 1,two,4,5, 24Department of Gastroenterology and Hepatology, mAChR4 Antagonist Storage & Stability University Hospital, Coventry CV2 2DX, UK; [email protected] Warwick Healthcare School, University of Warwick, Coventry CV4 7HL, UK School of Engineering, University of Warwick, Coventry CV4 7AL, UK; [email protected] (H.T.); [email protected] (E.D.); [email protected] (J.A.C.) Faculty of Wellness Life Sciences, Coventry University, Coventry CV1 5FB, UK Leicester Cancer Analysis Centre, University of Leicester, Leicester LE1 7RH, UK Correspondence: [email protected]; Tel.: +44-2476-Citation: Bannaga, A.S.; Tyagi, H.; Daulton, E.; Covington, J.A.; Arasaradnam, R.P. Exploratory Study Using Urinary Volatile Organic Compounds for the Detection of Hepatocellular Carcinoma. Molecules 2021, 26, 2447. https://doi.org/ 10.3390/molecules26092447 Academic Editors: Natalia Drabinska and Ben de Lacy Costello Received: 25 March 2021 Accepted: 20 April 2021 Published: 22 AprilAbstract: Hepatocellular carcinoma (HCC) biomarkers are lacking in clinical practice. We therefore explored the pattern and composition of urinary volatile organic compounds (VOCs) in HCC sufferers. This was completed so that you can assess the feasibility of a prospective non-invasive test for HCC, and to improve our understanding of the disease. This pilot study recruited 58 participants, of whom 20 were HCC cases and 38 had been non-HCC cases. The non-HCC instances included healthful folks and sufferers with different stages of non-alcoholic fatty liver illness (NAFLD), which includes these with and without the need of fibrosis. Urine was analysed utilizing gas chromatography on mobility spectrometry (GC MS) and gas chromatography ime-of-flight mass spectrometry (GC OF-MS). GC MS was in a position to separate HCC from fibrotic situations with an location beneath the curve (AUC) of 0.97 (0.91.00), and from non-fibrotic instances with an AUC of 0.62 (0.48.76). For GC-TOF-MS, a subset of samples was analysed in which sev.
