Product Name :
VU0364770 hydrochloride
Description:
VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively.
CAS:
1414842-70-8
Molecular Weight:
269.13
Formula:
C12H10Cl2N2O
Chemical Name:
N-(3-chlorophenyl)pyridine-2-carboxamide; chlorohydrogen
Smiles :
Cl.{{Tobramycin} medchemexpress|{Tobramycin} Anti-infection|{Tobramycin} Protocol|{Tobramycin} In Vitro|{Tobramycin} custom synthesis|{Tobramycin} Epigenetic Reader Domain} O=C(NC1C=C(Cl)C=CC=1)C1C=CC=CN=1
InChiKey:
CZNNJOSFWZBQKH-UHFFFAOYSA-N
InChi :
InChI=1S/C12H9ClN2O.ClH/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11;/h1-8H,(H,15,16);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.{{α-MSH} MedChemExpress|{α-MSH} GPCR/G Protein|{α-MSH} Protocol|{α-MSH} In stock|{α-MSH} manufacturer|{α-MSH} Cancer} 8 μM.PMID:23829314 VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively.|Product information|CAS Number: 1414842-70-8|Molecular Weight: 269.13|Formula: C12H10Cl2N2O|Chemical Name: N-(3-chlorophenyl)pyridine-2-carboxamide; chlorohydrogen|Smiles: Cl.O=C(NC1C=C(Cl)C=CC=1)C1C=CC=CN=1|InChiKey: CZNNJOSFWZBQKH-UHFFFAOYSA-N|InChi: InChI=1S/C12H9ClN2O.ClH/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11;/h1-8H,(H,15,16);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (371.57 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
