Figure 8 displays the results of regulating intracellular GSH focus in tumors with WT macrophages eight(a), 8 (c) and HIF-1a-deficient macrophages eight(b), eight(d). GSH depletion is simulated by augmenting the GSH degradation coefficient kd in Eq. (19) to different extents
From the determine we can see that GSH concentration in tumors with HIF-1a KO...